When it comes to ulcerative colitis, you may not know what to do. PUC symptoms are unpredictable and may keep your child from participating in activities he or she enjoys.
You’ve both learned to cope with the unexpected flare-ups. You’d give just about anything to help relieve your child’s symptoms and help him or her do more of the things kids like to do. You wonder what the future holds.
If your child is still experiencing unpredictable flare-ups and other PUC symptoms, talk to your child’s doctor. Help may be within reach. 
PUC is a condition that occurs in children younger than 17 years of age and causes inflammation in the colon or large intestine. It is among the most common gastrointestinal conditions managed by gastroenterologists in the United States.
Symptoms of PUC include blood in the stool or bloody diarrhea, frequent bowel movements, rectal bleeding, stomach pain, cramping, joint pain, fatigue, and weight loss.
The direct cause of PUC is unknown. But we do know that children may be more likely to experience it if ulcerative colitis is part of their family’s medical history.
PUC symptoms begin when the immune system attacks healthy cells in a child’s body, for reasons we do not yet understand. Normally, the immune system (the body’s natural defense system) protects the body from bacteria, viruses, and other foreign agents. When children have PUC, their immune system incorrectly targets their gastrointestinal tract.  This causes inflammation, leading to the symptoms and flares usually experienced with PUC.
PUC is usually seen in adolescents, but younger children also have been seen with the disease.
Symptoms of PUC can be mild, moderate, or severe and may develop over time or very suddenly.
Symptoms typically include:
These symptoms can interrupt your child’s daily routine. If your son or daughter is taking medication and is still experiencing symptoms, his or her symptoms aren’t really under control. While you and your child may have learned to live with your current treatment, you may not have to anymore—there are more options available. 
Only your doctor can recommend a course of treatment after checking your health condition. REMICADE® (infliximab) can cause serious side effects such as lowering your ability to fight infections. Some patients, especially those 65 years and older, have had serious infections caused by viruses, fungi or bacteria that have spread throughout the body, including tuberculosis (TB) and histoplasmosis. Some of these infections have been fatal. Your doctor should monitor you closely for signs and symptoms of TB during treatment with REMICADE®.
Unusual cancers have been reported in children and teenage patients taking TNF-blocker medicines. Hepatosplenic T-cell lymphoma, a rare form of fatal lymphoma, has occurred mostly in teenage or young adult males with Crohn’s disease or ulcerative colitis who were taking REMICADE® and azathioprine or 6-mercaptopurine. For children and adults taking TNF blockers, including REMICADE®, the chances of getting lymphoma or other cancers may increase.
You should discuss any concerns about your health and medical care with your doctor.
What should I tell my doctor before I take REMICADE®?
You should let your doctor know if you have or ever had any of the following:
Also tell your doctor if you:
What should I watch for and talk to my doctor about before or while taking REMICADE®?
The following serious (sometimes fatal) side effects have been reported in people taking REMICADE®.
You should tell your doctor right away if you have any of the signs listed below:
You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.