How REMICADE® Works
A child’s immune system works around the clock to protect against bacteria, viruses, and other foreign agents. When your child has pediatric ulcerative colitis (PUC) , the immune system becomes overactive and produces excess amounts of a protein called tumor necrosis factor-alpha, or TNF-alpha.
The presence of excess TNF-alpha causes a child’s immune system to attack healthy cells in the gastrointestinal tract. This leads to the inflammation children experience as the symptoms of PUC . REMICADE® has been shown to block the action of TNF-alpha. This inhibits the underlying causes of inflammation.
See how REMICADE® works in the illustration below:
REMICADE® is not for everyone
REMICADE® is a strong medication that can cause serious side effects. Only your child’s doctor can decide if REMICADE® is right for your child.
REMICADE® can lower your ability to fight infections. Serious and sometimes fatal events can occur. There have been reports of serious infections including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses that have spread throughout the body. Lymphoma, including a fatal kind called hepatosplenic T-cell lymphoma, and other cancers have been reported in children and adults taking REMICADE®. Some people with heart failure should not take REMICADE®. Other serious side effects reported include skin cancer, hepatitis B, liver injury, blood problems, allergic reactions, nervous system problems, or lupus-like syndrome. To learn more about these and other risks, please read the Important Safety Information and the Medication Guide , and talk with your doctor.
REMICADE® is given by IV infusion
If your doctor decides REMICADE® is right for your child, he or she will receive it as an intravenous (IV) infusion  from a healthcare professional over a 2-hour period. REMICADE® is the only medication of its kind to require as few as 6 treatments a year after 3 starter doses. That’s once every 8 weeks. 
REMICADE® is given either in your doctor’s office or in a treatment center, so someone will always be close by while your child receives treatment and for a period of time afterward to monitor him or her for side effects. And because REMICADE® is infused, it goes directly into your child’s bloodstream and gets right to work. Plus, REMICADE® is nonsedating, so your child should be able to resume his or her daily activities, as advised by your doctor.
Customized dosing based on body weight
Before each infusion, your doctor will calculate the right amount of medication for your child, based on body weight.
How should my child receive REMICADE®?
- Your child will be given REMICADE® through a needle placed in a vein (IV, or intravenous infusion ) in his or her arm
- The doctor may decide to give your child medication before starting the REMICADE® infusion, to prevent or lessen side effects
- Only a healthcare professional should prepare the medication and administer it to your child
- REMICADE® will be given to your child over a period of at least 2 hours
- If your child has side effects  from REMICADE®, the infusion may need to be adjusted or stopped. In addition, your child’s healthcare professional may decide to treat your child’s symptoms
- A healthcare professional will monitor your child during the REMICADE® infusion and for a period of time afterward for side effects. The doctor may do certain tests while your child is taking REMICADE® to monitor him or her for side effects and to see how well your child responds to the treatment
- Your doctor will determine the right dose of REMICADE® for your child and how often he or she should receive it
- Make sure to discuss with the doctor  when your child will receive infusions and be sure to come in for all of your child’s infusions and follow-up appointments