How REMICADE Works to Treat Crohn's Disease in Adults

Crohn’s is an inflammatory bowel disease that causes inflammation of the gastrointestinal tract in both men and women. It usually occurs in the lower part of the small intestine and typically leads to persistent diarrhea, abdominal pain, fever, and at times rectal bleeding.

• The immune system protects the body by responding to "invaders" like bacteria, viruses, and other foreign matter that enter your body by producing antibodies and putting them into action to fight off the "invaders".  In Crohn's disease, TNF can cause your immune system to attack healthy tissues in your body and cause inflammation and damage.
• If Crohn's is left untreated, it can cause permanent damage to the tissue in the digestive or gastrointestinal tract.
• REMICADE helps put Crohn's into remission by neutralizing TNF-alpha. REMICADE is therefore called a TNF "antagonist" that works with your body's immune system to block TNF-alpha, reducing inflammation.
• REMICADE targets, binds to, and blocks TNF-alpha in the affected area to relieve painful symptoms of Crohn’s.
• REMICADE is the first and only treatment approved for moderate to severe Crohn's disease in adults and children who haven't responded well to other therapies.

By staying on maintenance therapy with REMICADE, you can keep Crohn’s under control and continue to enjoy freedom from flare-ups. Maintenance treatment requires a two-hour IV infusion of REMICADE just once every eight weeks after the first three doses — that could be as few as six times a year.

Individual results may vary. Talk to your doctor to see if REMICADE is right for you. Please read the Medication Guide and discuss any questions or symptoms with your doctor.

For more detailed information on treating Crohn’s disease, please visit the following resource:

• Crohn’s Disease and REMICADE